Riou M, Charles AL, Enache I, Evrard C, Pistea C, Giannini M, Charloux A, Geny B. Acute Severe Hypoxia Decreases Mitochondrial Chain Complex II Respiration in Human Peripheral Blood Mononuclear Cells. Int J Mol Sci. 2025 Jan 15;26(2):705. doi: 10.3390/ijms26020705. PMID: 39859418; PMCID: PMC11765662.
Publications 2024
Charles AL, Giannini M, Meyer A, Charloux A, Talha S, Vogel T, Raul JS, Wolff V, Geny B. Cannabis (THC) Aggravates the Deleterious Effects of Alcohol (EtOH) on Skeletal Muscles' Mitochondrial Respiration: Modulation by Age and Metabolic Phenotypes. Biology (Basel). 2024 Dec 21;13(12):1080. doi: 10.3390/biology13121080. PMID: 39765747; PMCID: PMC11673998.
Bellissard A, Kuntz S, Lejay A, Chakfé N. Systematic Review of Femoral Artery Stent Fractures. EJVES Vasc Forum. 2024 Aug 17;62:48-56. doi: 10.1016/j.ejvsvf.2024.08.001. PMID: 39328303; PMCID: PMC11426108.
Piotin A, Oulehri W, Charles AL, Tacquard C, Collange O, Mertes PM, Geny B. Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review. Antioxidants (Basel). 2024 Jul 29;13(8):920. doi: 10.3390/antiox13080920. PMID: 39199166; PMCID: PMC11352116.
Riou M, Coste F, Meyer A, Enache I, Talha S, Charloux A, Reboul C, Geny B. Mechanisms of Pulmonary Vasculopathy in Acute and Long-Term COVID-19: A Review. Int J Mol Sci. 2024 Apr 30;25(9):4941. doi: 10.3390/ijms25094941. PMID: 38732160; PMCID: PMC11084496.
Paradis S, Charles AL, Giannini M, Meyer A, Lejay A, Talha S, Laverny G, Charloux A, Geny B. Targeting Mitochondrial Dynamics during Lower-Limb Ischemia Reperfusion in Young and Old Mice: Effect of Mitochondrial Fission Inhibitor-1 (mDivi-1). Int J Mol Sci. 2024 Apr 4;25(7):4025. doi: 10.3390/ijms25074025. PMID: 38612835; PMCID: PMC11012338.
Charlot A, Bringolf A, Mallard J, Charles AL, Niederhoffer N, Duteil D, Pagano AF, Geny B, Zoll J. Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet. Front Nutr. 2024 Mar 20;11:1366883. doi: 10.3389/fnut.2024.1366883. PMID: 38571752; PMCID: PMC10987868.
Oulehri W, Persello A, Blangy-Letheule A, Tacquard C, Rozec B, Charles AL, Geny B, Lauzier B, Mertes PM, Collange O. NButGT Reinforces the Beneficial Effects of Epinephrine on Cardiac Mitochondrial Respiration, Lactatemia and Cardiac Output in Experimental Anaphylactic Shock. Int J Mol Sci. 2024 Mar 14;25(6):3316. doi: 10.3390/ijms25063316. PMID: 38542290; PMCID: PMC10970273.
Charles AL, Charloux A, Vogel T, Raul JS, Kindo M, Wolff V, Geny B. Cumulative Deleterious Effects of Tetrahydrocannabinoid (THC) and Ethanol on Mitochondrial Respiration and Reactive Oxygen Species Production Are Enhanced in Old Isolated Cardiac Mitochondria. Int J Mol Sci. 2024 Feb 2;25(3):1835. doi: 10.3390/ijms25031835. PMID: 38339113; PMCID: PMC10855679.
Boutonnet L, Mallard J, Charles AL, Hucteau E, Gény B, Lejay A, Grandperrin A. Autologous mitochondrial transplantation in male mice as a strategy to prevent deleterious effects of peripheral ischemia-reperfusion. Am J Physiol Cell Physiol. 2024 Feb 1;326(2):C449-C456. doi: 10.1152/ajpcell.00639.2023. Epub 2023 Dec 25. PMID: 38145293.
Publications 2023
Riou M, Enache I, Sauer F, Charles AL, Geny B. Targeting Mitochondrial Metabolic Dysfunction in Pulmonary Hypertension: Toward New Therapeutic Approaches? Int J Mol Sci. 2023 May 31;24(11):9572. doi: 10.3390/ijms24119572. PMID: 37298522; PMCID: PMC10253387.
Publications 2022
Alfatni A, Charles AL, Sauer F, Riou M, Goupilleau F, Talha S, Meyer A, Andres E, Kindo M, Mazzucotelli JP, Epailly E, Geny B. Peripheral Blood Mononuclear Cells Mitochondrial Respiration and Superoxide Anion after Heart Transplantation. J Clin Med. 2022 Dec 6;11(23):7247. doi: 10.3390/jcm11237247. PMID: 36498821; PMCID: PMC9735976.
Barnig C, Lutzweiler G, Giannini M, Lejay A, Charles AL, Meyer A, Geny B. Resolution of Inflammation after Skeletal Muscle Ischemia-Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins. Antioxidants (Basel). 2022 Jun 20;11(6):1213. doi: 10.3390/antiox11061213. PMID: 35740110; PMCID: PMC9220296.
Oulehri W, Collange O, Tacquard C, Bellou A, Graff J, Charles AL, Geny B, Mertes PM. Impaired Myocardial Mitochondrial Function in an Experimental Model of Anaphylactic Shock. Biology (Basel). 2022 May 10;11(5):730. doi: 10.3390/biology11050730. PMID: 35625458; PMCID: PMC9139016.
Helfer E, Kuntz S, Dion D, Heim F, Georg Y, Thaveau F, Lejay A, Chakfé N. Vascular grafts collagen coating resorption and healing process in humans. JVS Vasc Sci. 2022 Mar 25;3:193-204. doi: 10.1016/j.jvssci.2022.02.001. PMID: 35495568; PMCID: PMC9046442.
Levy D, Giannini M, Oulehri W, Riou M, Marcot C, Pizzimenti M, Debrut L, Charloux A, Geny B, Meyer A. Long Term Follow-Up of Sarcopenia and Malnutrition after Hospitalization for COVID-19 in Conventional or Intensive Care Units. Nutrients. 2022 Feb 21;14(4):912. doi: 10.3390/nu14040912. PMID: 35215562; PMCID: PMC8880495.
Sauer F, Riou M, Charles AL, Meyer A, Andres E, Geny B, Talha S. Pathophysiology of Heart Failure: A Role for Peripheral Blood Mononuclear Cells Mitochondrial Dysfunction? J Clin Med. 2022 Jan 29;11(3):741. doi: 10.3390/jcm11030741. PMID: 35160190; PMCID: PMC8836880.
Publications 2021
Guillot M, Charles AL, Lejay A, Pottecher J, Meyer A, Georg I, Goupilleau F, Diemunsch P, Geny B. Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia-Reperfusion in Mice. Eur J Vasc Endovasc Surg. 2021 Dec;62(6):953-959. doi: 10.1016/j.ejvs.2021.06.032. Epub 2021 Aug 5. PMID: 34364768.
Jinnouchi H, Sato Y, Bhoite RR, Kuntz SH, Sakamoto A, Kutyna M, Torii S, Mori M, Kawakami R, Amoa FC, Kolodgie FD, Virmani R, Finn AV. Intravascular imaging and histological correlates of medial and intimal calcification in peripheral artery disease. EuroIntervention. 2021 Oct 1;17(8):e688-e698. doi: 10.4244/EIJ-D-20-01336. PMID: 33896763; PMCID: PMC9724947.
Kuntz S, Lejay A, Chakfé N. Subintimal Angioplasty in the Superficial Femoral Artery: A Real Long Term Option Demonstrated by Histology. EJVES Vasc Forum. 2021 Aug 25;52:49-50. doi: 10.1016/j.ejvsvf.2021.08.003. PMID: 34522909; PMCID: PMC8424509.
Kuntz S, Gangloff H, Naamoune H, Lejay A, Virmani R, Chakfé N. Automated Histological Segmentation on Micro Computed Tomography Images of Atherosclerotic Arteries. Eur J Vasc Endovasc Surg. 2021 Apr;61(4):714-715. doi: 10.1016/j.ejvs.2021.01.012. Epub 2021 Feb 13. PMID: 33589329.
Pizzimenti M, Charles AL, Riou M, Thaveau F, Chakfé N, Geny B, Lejay A. Usefulness of Platelet-to-Lymphocyte Ratio as a Marker of Sarcopenia for Critical Limb Threatening Ischemia. Ann Vasc Surg. 2021 Apr;72:72-78. doi: 10.1016/j.avsg.2020.05.027. Epub 2020 May 29. PMID: 32479878.
Kuntz SH, Jinnouchi H, Kutyna M, Torii S, Cornelissen A, Sakamoto A, Sato Y, Fuller DT, Schwein A, Ohana M, Gangloff H, Lejay A, Finn AV, Chakfé N, Virmani R. Co-Registration of Peripheral Atherosclerotic Plaques Assessed by Conventional CT Angiography, MicroCT and Histology in Patients with Chronic Limb Threatening Ischaemia. Eur J Vasc Endovasc Surg. 2021 Jan;61(1):146-154. doi: 10.1016/j.ejvs.2020.08.037. Epub 2020 Nov 10. PMID: 33187923.
Publications 2020
Barberio M, Felli E, Diana M, Marescaux J, Al-Taher M, Georg I, Tetsi L, Lejay A, Charles AL, Lugnier C, Geny B. Hyperspectral Imaging Quantification of Mouse Limb Microcirculation Using an Ischemia Reperfusion Model with Phosphodiesterase 5 Inhibitor Preconditioning. J Laparoendosc Adv Surg Tech A. 2020 Sep;30(9):942-947. doi: 10.1089/lap.2020.0364. Epub 2020 Jun 29. PMID: 32609046.
Pizzimenti M, Meyer A, Charles AL, Giannini M, Chakfé N, Lejay A, Geny B. Sarcopenia and peripheral arterial disease: a systematic review. J Cachexia Sarcopenia Muscle. 2020 Aug;11(4):866-886. doi: 10.1002/jcsm.12587. Epub 2020 Jul 10. PMID: 32648665; PMCID: PMC7432591.
Lugnier C, Meyer A, Talha S, Geny B. Cyclic nucleotide phosphodiesterases: New targets in the metabolic syndrome? Pharmacol Ther. 2020 Apr;208:107475. doi: 10.1016/j.pharmthera.2020.107475. Epub 2020 Jan 9. PMID: 31926200.
Boulghobra D, Coste F, Geny B, Reboul C. Exercise training protects the heart against ischemia-reperfusion injury: A central role for mitochondria? Free Radic Biol Med. 2020 May 20;152:395-410. doi: 10.1016/j.freeradbiomed.2020.04.005. Epub 2020 Apr 12. PMID: 32294509.
Riou M, Alfatni A, Charles AL, Andrès E, Pistea C, Charloux A, Geny B. New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases. J Clin Med. 2020 Apr 26;9(5):1253. doi: 10.3390/jcm9051253. PMID: 32357474; PMCID: PMC7287602.
Kuntz SH, Torii S, Jinnouchi H, Cornelissen A, Sakamoto A, Sato Y, Kutyna M, Romero ME, Lejay A, Schwein A, Bonnin E, Finn AV, Chakfé N, Virmani R. Pathology and Multimodality Imaging of Acute and Chronic Femoral Stenting in Humans. JACC Cardiovasc Interv. 2020 Feb 24;13(4):418-427. doi: 10.1016/j.jcin.2019.10.060. PMID: 32081234.
Tacquard C, Oulehri W, Collange O, Garvey LH, Nicoll S, Tuzin N, Geny B, Mertes PM. Treatment with a platelet-activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock. Clin Exp Allergy. 2020 Mar;50(3):383-390. doi: 10.1111/cea.13540. Epub 2019 Dec 10. PMID: 31755606.
Riou M,Pizzimenti M, Enache I, Charloux A, Canuet M, Andres E, Talha S, Meyer A, Geny B. Skeletal and Respiratory Muscle Dysfunctions in Pulmonary Arterial Hypertension. J Clin Med. 2020 Feb 3;9(2):410. doi: 10.3390/jcm9020410. PMID: 32028638; PMCID: PMC7073630.
Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B. Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases. J Clin Med. 2020 Jan 22;9(2):311. doi: 10.3390/jcm9020311. PMID: 31979097; PMCID: PMC7073649.
Publications 2019
Lejay A, Geny B, Chakfé N. When the Vicious Circle Begins…. Eur J Vasc Endovasc Surg. 2019 Dec;58(6):902. doi: 10.1016/j.ejvs.2019.06.019. Epub 2019 Jul 24. PMID: 31351833.
Pizzimenti M, Riou M, Charles AL, Talha S, Meyer A, Andres E, Chakfé N, Lejay A, Geny B. The Rise of Mitochondria in Peripheral Arterial Disease Physiopathology: Experimental and Clinical Data. J Clin Med. 2019 Dec 2;8(12):2125. doi: 10.3390/jcm8122125. PMID: 31810355; PMCID: PMC6947197.
Ederlé C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B. Mitochondrial Function in Peripheral Blood Mononuclear Cells (PBMC) Is Enhanced, Together with Increased Reactive Oxygen Species, in Severe Asthmatic Patients in Exacerbation. J Clin Med. 2019 Oct 3;8(10):1613. doi: 10.3390/jcm8101613. PMID: 31623409; PMCID: PMC6833034.
Lejay A, Charles AL, Georg I, Goupilleau F, Delay C, Talha S, Thaveau F, Chakfé N, Geny B. Critical Limb Ischaemia Exacerbates Mitochondrial Dysfunction in ApoE-/- Mice Compared with ApoE+/+ Mice, but N-acetyl Cysteine still Confers Protection. Eur J Vasc Endovasc Surg. 2019 Oct;58(4):576-582. doi: 10.1016/j.ejvs.2019.03.028. Epub 2019 Aug 14. PMID: 31422047.
Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B. Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle. Antioxidants (Basel). 2019 Jun 8;8(6):168. doi: 10.3390/antiox8060168. PMID: 31181751; PMCID: PMC6616544.
Lejay A, Geny B, Kolh P, Chakfe N. Remote Ischaemic Preconditioning in Vascular Surgery: Is it Worth the Effort? Eur J Vasc Endovasc Surg. 2019 Jun;57(6):757-758. doi: 10.1016/j.ejvs.2019.04.012. Epub 2019 May 10. PMID: 31085005.
Leardini-Tristao M, Charles AL, Lejay A, Pizzimenti M, Meyer A, Estato V, Tibiriçá E, Andres E, Geny B. Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. J Clin Med. 2019 May 10;8(5):653. doi: 10.3390/jcm8050653. PMID: 31083472; PMCID: PMC6571759.
Leardini-Tristao M, Charles AL, Lejay A, Pizzimenti M, Meyer A, Estato V, Tibiriçá E, Andres E, Geny B. Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. J Clin Med. 2019 May 10;8(5):653. doi: 10.3390/jcm8050653. PMID: 31083472; PMCID: PMC6571759.
Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B. Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress. Antioxidants (Basel). 2019 Apr 7;8(4):93. doi: 10.3390/antiox8040093. PMID: 30959961; PMCID: PMC6523910.
Publications 2018
Lejay A, Paradis S, Lambert A, Charles AL, Talha S, Enache I, Thaveau F, Chakfe N, Geny B. N-Acetyl Cysteine Restores Limb Function, Improves Mitochondrial Respiration, and Reduces Oxidative Stress in a Murine Model of Critical Limb Ischaemia. Eur J Vasc Endovasc Surg. 2018 Nov;56(5):730-738. doi: 10.1016/j.ejvs.2018.07.025. Epub 2018 Aug 29. PMID: 30172667.
Pottecher J, Adamopoulos C, Lejay A, Bouitbir J, Charles AL, Meyer A, Singer M, Wolff V, Diemunsch P, Laverny G, Metzger D, Geny B. Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? Front Physiol. 2018 May 22;9:579. doi: 10.3389/fphys.2018.00579. PMID: 29872405; PMCID: PMC5972292.
Lejay A, Colvard B, Magnus L, Dion D, Georg Y, Papillon J, Thaveau F, Geny B, Swanström L, Heim F, Chakfé N. Explanted Vascular and Endovascular Graft Analysis: Where Do We Stand and What Should We Do? Eur J Vasc Endovasc Surg. 2018 Apr;55(4):567-576. doi: 10.1016/j.ejvs.2018.01.022. Epub 2018 Feb 23. PMID: 29478909.
Publications 2017
Lejay A, Monnot A, Georg Y, Colvard B, Thaveau F, Geny B, Chakfé N. Pathology of graft and stent-graft infections: Lessons learned from examination of explant materials. Semin Vasc Surg. 2017 Jun-Sep;30(2-3):70-74. doi: 10.1053/j.semvascsurg.2017.10.002. Epub 2017 Oct 22. PMID: 29248122.
Lejay A, Laverny G, Paradis S, Schlagowski AI, Charles AL, Singh F, Zoll J, Thaveau F, Lonsdorfer E, Dufour S, Favret F, Wolff V, Metzger D, Chakfe N, Geny B. Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia. Front Physiol. 2017 Jul 25;8:523. doi: 10.3389/fphys.2017.00523. PMID: 28790926; PMCID: PMC5524729.
Charles AL, Guilbert AS, Guillot M, Talha S, Lejay A, Meyer A, Kindo M, Wolff V, Bouitbir J, Zoll J, Geny B. Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level. Front Physiol. 2017 Feb 6;8:52. doi: 10.3389/fphys.2017.00052. PMID: 28220081; PMCID: PMC5292410.
Tetsi L, Charles AL, Paradis S, Lejay A, Talha S, Geny B, Lugnier C. Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions. Cell Mol Life Sci. 2017 May;74(10):1883-1893. doi: 10.1007/s00018-016-2446-0. Epub 2016 Dec 30. PMID: 28039524; PMCID: PMC11107545.
Delay C, Paradis S, Charles AL, Thaveau F, Chenesseau B, Zoll J, Chakfe N, Geny B, Lejay A. Physiopathologie de l’ischémie-reperfusion et du conditionnement ischémique du muscle squelettique – applications cliniques pour le chirurgien vasculaire [Skeletal muscle ischemia-reperfusion and ischemic conditioning pathophysiology-clinical applications for the vascular surgeon]. J Med Vasc. 2017 Feb;42(1):29-38. French. doi: 10.1016/j.jmv.2016.11.001. Epub 2016 Dec 15. PMID: 27989659.
Publications 2016
Paradis S, Charles AL, Meyer A, Lejay A, Scholey JW, Chakfé N, Zoll J, Geny B. Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C968-82. doi: 10.1152/ajpcell.00356.2015. Epub 2016 Apr 13. PMID: 27076618; PMCID: PMC4935201.
Pottecher J, Kindo M, Chamaraux-Tran TN, Charles AL, Lejay A, Kemmel V, Vogel T, Chakfe N, Zoll J, Diemunsch P, Geny B. Skeletal muscle ischemia-reperfusion injury and cyclosporine A in the aging rat. Fundam Clin Pharmacol. 2016 Jun;30(3):216-25. doi: 10.1111/fcp.12180. Epub 2016 Feb 26. PMID: 26787364.
Publications 2015
Charles AL, Lejay A, Zoll J, Chakfe N, Geny B. Re: 'Protective Effect of Focal Adhesion Kinase against Skeletal Muscle Reperfusion Injury after Acute Limb Ischemia'. Eur J Vasc Endovasc Surg. 2015 Jun;49(6):753. doi: 10.1016/j.ejvs.2015.02.016. Epub 2015 Mar 30. PMID: 25837988.
Lejay A, Fang F, John R, Van JA, Barr M, Thaveau F, Chakfe N, Geny B, Scholey JW. Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. J Mol Cell Cardiol. 2016 Feb;91:11-22. doi: 10.1016/j.yjmcc.2015.12.020. Epub 2015 Dec 21. PMID: 26718721.
Lejay A, Choquet P, Thaveau F, Singh F, Schlagowski A, Charles AL, Laverny G, Metzger D, Zoll J, Chakfe N, Geny B. A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology. Eur J Vasc Endovasc Surg. 2015 Feb;49(2):205-12. doi: 10.1016/j.ejvs.2014.12.010. Epub 2015 Jan 8. PMID: 25579876.
Publications 2014
Mansour Z, Charles AL, Kindo M, Pottecher J, Chamaraux-Tran TN, Lejay A, Zoll J, Mazzucotelli JP, Geny B. Remote effects of lower limb ischemia-reperfusion: impaired lung, unchanged liver, and stimulated kidney oxidative capacities. Biomed Res Int. 2014;2014:392390. doi: 10.1155/2014/392390. Epub 2014 Aug 10. PMID: 25180180; PMCID: PMC4142554.
Lejay A, Meyer A, Schlagowski AI, Charles AL, Singh F, Bouitbir J, Pottecher J, Chakfé N, Zoll J, Geny B. Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscle. Int J Biochem Cell Biol. 2014 May;50:101-5. doi: 10.1016/j.biocel.2014.02.013. Epub 2014 Feb 26. PMID: 24582887.
Meyer A, Charles AL, Zoll J, Guillot M, Lejay A, Singh F, Schlagowski AI, Isner-Horobeti ME, Pistea C, Charloux A, Geny B. Cryopreservation with dimethyl sulfoxide prevents accurate analysis of skinned skeletal muscle fibers mitochondrial respiration. Biochimie. 2014 May;100:227-33. doi: 10.1016/j.biochi.2014.01.014. Epub 2014 Jan 25. PMID: 24472439.
